Last Notes
This looks like it might be good. I think I'm going to watch it tonight. Don't fucking spoil it for me if you've seen it.
https://npub1un5y07dnu20fxzelq5scweuz37xa6kkpwl66634xv9h49ewr04kswpevsy.blossom.band/01e889f11b1204d28b9e0de193d5eaf266042d654c5c1c10d48edb0f9f0d50b7.jpg
Which client is going to add support for @nprofile…2r4m's ONESENDAI's 3D models first? https://blossom.dreamith.to/e439b436da8511e59c4c388033b92e06e7b7aacfd724cfe4e81e67e4b8ee23d8.jpeg
https://npub1w3z04t3z6n2f88yptqvaeg7ysgkzp96ch7r2l3nrvhd4770k0hds43lfey.blossom.band/2b8bc7ff34698545483812df61bc8d4fdf65d7d672836818ffb483761738681d.mp4
🚨 [ #BuZZerFeeD ] 🌎🕓 -3 UTC
https://cdn.nostrcheck.me/137ab849b9d95b85acf23668e3b505530fc944c6b0063b46c515c0a5fc014278.jpeg
#Sports 🌐 #PREDYX
I spent way too much time staring at this album cover in my parents’ collection as a kid.
https://onlydans.blossom.band/d19bd38d91cc1adfc8717104c34dec059bd31008f095bf718b225aa9672e3378.jpg
If you get enough visitors you could probably build a racoon obstacle course 😅
May I have your attention please:
@nprofile…w9ld sucks tranny dick.
That is all.
The one nice thing about our shitty hospital back home is that they would designate me a caregiver and charge my meals to our insurance, because fuck those insurance companies.
They don't do that here. I just paid $22 for my dinner.
VIP seats for @nprofile…vlr0 https://blossom.dreamith.to/b55675d1a5561c6750cdea7ac864392a5ff21c1d07845cad8eb279f98c41d964.jpeg
One of the fun quirks of Nostr is that you never have any real proof a user has actually left, even if their account says it’s been “deleted.” Some clients will ban npubs with a delete flag from using them again, but there’s a fairly reliable way to reverse that. And as long as the nsec isn’t lost, someone can just lurk.
For example, @npub1ll9…xszt isn’t really deleted, because the profile has no deletion event, and even though the last visible post is from over a month ago, the user just updated their kind 0 profile metadata less than two days ago.
What this user didn’t realize is that they only changed the "display_name" field to “Deleted“ and not the alternate "displayName" field that was left behind by another client, so it’s trivially easy figure out who it is.
We see you, friend, 😏
https://blossom.primal.net/e0b6c36d6b280d1c7617bf6cecc51f5654b110ad777d80fa8fd8b15d11ab44bb.png
https://npub1un5y07dnu20fxzelq5scweuz37xa6kkpwl66634xv9h49ewr04kswpevsy.blossom.band/74ecf80e64ab992a22e3dde3f41aed61a6a07befdfa21d6439d91a3f95c9a60d.jpg
”Nice icebergs youse got there. Be a real shame if sumthin’ was to happen to ‘em.” — Don Trump Corleone
https://blossom.primal.net/e61c79346272dcc6912a315e22296c7adfbec31bed9bee1d25b263aaeab60250.gif
I'm pretty sure it was the CIA that spun this narrative that transparency is more important than privacy.
None of what you just said even remotely applies to Monero, which is what we're talking about here.
The whole Omarchy is SUS AS FUCK.
One 👏 of 👏 us 👏
One 👏 of 👏 us 👏
✊
I think it means he contacted support@nostr.com for account removal.
Satoshi said he was moving on to other things. Many of the Monero devs are anonymous. I sometimes wonder if he's been quietly contributing under a different nym.
📸 [ #Picstr ] Gregory Fisher
https://cdn.nostrcheck.me/550a5c5ee0e8f3ff9a0264c9dbd7a1643124bf93a9201416653b8df4c3a9dee5.jpeg
Buffalo Bills quarterback Josh Allen (17) passes under pressure from Detroit Lions defensive end Aidan Hutchinson (97) during the first half at New Highmark Stadium.
#PlebChain 🌐 #PREDYX
You're not doing right. Go play blackjack and then when you're drunk enough ask a stripper to marry you.
📺 [ #GaMeTiMe ]
🏴Brentford *2x0* Chelsea🏴
⚽🇧🇷 Igor Thiago / 83' 🏆 *Premier League | 5ª Rodada* https://cdn.nostrcheck.me/67657b4a278b5955b8ee75b9686467f6a6e31c0aedab6249b8ce68ccf0238670.mp4
#Sports 🌐 #PREDYX
# Comparing mitragynine to opioids
Mitragynine has opioid activity—it is not pharmacologically separate from opioids. It is the main alkaloid in kratom and acts on the same μ-opioid receptor (“mu receptor”) targeted by morphine and other opioid painkillers. The useful comparison is therefore between mitragynine’s atypical opioid pharmacology and that of conventional opioid drugs, rather than “kratom compound versus opioid.”
The main functional differences concern how strongly it activates that receptor, what your body converts it into, and which other biological systems it affects.
1. It activates opioid receptors differently
Drugs such as morphine produce substantial μ-receptor activation, which contributes to both pain relief and potentially dangerous suppression of breathing. Mitragynine has comparatively low intrinsic efficacy at the human μ receptor: in laboratory studies, it behaves as a partial agonist, activating the receptor less strongly than a full agonist can in the same experimental system.
Think of receptor binding and receptor activation as two separate properties. A drug can attach to a receptor without turning its activity up very much. Consequently, “partial agonist” does not simply mean “a smaller dose of a strong opioid.” It describes a different ability to activate the receptor. The resulting effects still depend on the tissue, dose, and other compounds present.
This distinction is not unique to mitragynine. Buprenorphine is also a partial μ-opioid agonist, so not all conventional opioid medications belong on the “full agonist” side of the comparison. Sharing partial agonism does not make mitragynine and buprenorphine interchangeable.
2. Its metabolite is an important part of the story
Mitragynine can be converted into 7-hydroxymitragynine, commonly abbreviated 7-OH, through metabolism involving the enzyme CYP3A4. That metabolite has substantially greater opioid-receptor potency than mitragynine itself. Researchers demonstrated this conversion in human liver preparations and found that the metabolite accounted for much of mitragynine’s opioid-mediated pain relief in mice. The exact contribution to effects in humans is less firmly established.
This means that what mitragynine does in an isolated receptor experiment is not necessarily what happens after someone swallows it. The parent compound and the metabolites formed afterward can have different effects.
It also means that ordinary kratom leaf, purified mitragynine, and products enriched with 7-OH should not be treated as equivalent. Natural leaf contains relatively little 7-OH; concentrated products can expose someone directly to much larger amounts of this more potent compound.
3. Its effects are not exclusively opioid effects
Mitragynine’s pharmacology extends beyond μ-opioid receptors. For example, laboratory and animal studies have investigated interactions with alpha-2 adrenergic receptors, part of the system that responds to norepinephrine. However, receptor binding does not automatically establish a meaningful effect in humans, and the experimental findings are not simple enough to describe mitragynine as merely “an opioid plus a stimulant.”
There is another distinction here: kratom is a mixture, whereas mitragynine is one molecule. Kratom contains numerous other alkaloids, so an effect reported after taking kratom cannot automatically be attributed to mitragynine alone.
4. Breathing suppression may differ—but “it cannot suppress breathing” is wrong
There is experimental evidence that mitragynine’s respiratory effects differ considerably from those of morphine. In a 2025 rat study, intravenously administered mitragynine increased breathing frequency rather than suppressing it, whereas 7-OH and morphine both caused significant respiratory depression. Naloxone reversed the breathing suppression caused by 7-OH and morphine. High-dose mitragynine nevertheless caused seizure-like toxicity in some animals. These findings do not establish a safe dose or a guaranteed respiratory ceiling for oral use in humans.
You may encounter an explanation that mitragynine favors G-protein signaling over β-arrestin recruitment, two processes associated with opioid-receptor activation. Laboratory studies support this distinctive signaling profile. But the popular conclusion—“it avoids β-arrestin, therefore it cannot cause an opioid overdose”—goes beyond the evidence.
Broader opioid research suggests that low receptor-activating efficacy, not necessarily signaling bias alone, may explain some improved safety profiles. The relative contributions remain debated; neither characteristic is a guarantee against respiratory depression.
5. Dependence and other opioid-type effects remain possible
Kratom products can produce nausea, constipation, sedation, tolerance, physical dependence, and withdrawal. Their atypical pharmacology does not eliminate these possibilities. Human evidence also does not establish a reliable, universal conversion between a quantity of mitragynine and an equivalent dose of a prescription opioid. Kratom and its alkaloids are not FDA-approved treatments for pain or opioid withdrawal.
Bottom line: Mitragynine is best understood as an atypical opioid-active compound with relatively low μ-receptor efficacy, additional non-opioid actions, and a more potent opioid metabolite. Those differences can meaningfully change its effects compared with morphine—but they do not make it opioid-free, non-dependence-forming, or incapable of serious toxicity. Mitragynine and concentrated 7-OH are especially important not to conflate.
Down, down, down by the river...
You're not gonna pull out 10k cash and put it all on black?
That's part of it. We protect the stupid and weak from harming themselves, and we also reward mediocrity more and more in our society.
You should be able to walk into a shop and buy pharmaceutical grade heroin. Some people can handle it. Some can't. We should stop trying to protect the ones who can't and just let them self-select themselves for extinction.
That's what eugenics was trying to do but then everybody was like OMG that's so evil! 😭
Probably shouldn't use a surveillable currency then...
#nevent1q…yq7k
📰 [ oN This Day ] 🔹1984 Tim Raines is the first player with four consecutive 70-stolen-base seasons
https://cdn.nostrcheck.me/c00738e88f6077f289f0cdc789b5d1a532c43b7da8d33fec5eb0542a76335069.jpeg
MLB Outfielder
Tim Raines
#OTD | #PREDYX
🏈 Zay Flowers is doubtful for Sunday’s matchup against the Saints after suffering a hamstring injury in Week 1. He was limited in Friday’s practice. DT Nnamdi Madubuike is ruled out with a neck injury. #NFL
Physiognomy is undefeated. I tried shaving my head for a while when I was a young man, but I learned pretty quickly that I scare people away like that. I have very pronounced skull ridges where my cranial bones meet, so when people see me with a shaved head they think I look like a psychotic, violent criminal. The thing is, I do actually have lots of violent ideations and impulses, I just mostly keep them under control unless a get a good deal of alcohol in me. It's one of those legitimate generic sciences that was unfairly rejected around a century ago that we should probably revisit.
⚽ Cristiano Ronaldo, 41, has been called up for Portugal’s Nations League campaign under new coach Jorge Jesus. The veteran forward, who has scored 950+ career goals, may be entering his final season. #NationsLeague
Veracrypt hidden containers say hello
Lol probably using a Chinese LLM
Been thinking that even promoting a gimmick leads to walls because everyone's so jaded. Makes me think of promoting things in the opposite direction "it's an app for groups, it works with other apps in this space." Lead with the most boring framings possible, at least _that's_ different, because everyone's already drained of dopmine driven marketing and features.
Brains are crazy. My wife is awake now, but most of her brain has not activated yet according to the EEG. Mentally she's an infant. She can't speak or understand, and her muscle movements are involuntary. She's starting to recognize things though. Sometimes if I smile at her she'll smile back at me. I was showing her pictures and videos and it showed reactivity on the EEG that wasn't there a few days ago. Over the next several days they tell me more parts of her brain will come back online and she'll start getting her functions back.
If we want reliable DMs on nostr we need ask the scammers how they do it.
stinkie
https://npub1amq2jrn2dxz4sh2pm38el0ugv90c3gpkudj860m3hdys5lwk8rmq6ra744.blossom.band/3193cfc9ca47b6d6d481a2c6307180ee0900793040dcdcb4043a9e7654a31e92.mp4
#memepool #catstr