Last Notes
The one nice thing about our shitty hospital back home is that they would designate me a caregiver and charge my meals to our insurance, because fuck those insurance companies.
They don't do that here. I just paid $22 for my dinner.
# Nostr is completely fucking fucked up but nostr is awesome fuck you if you don't like nostr get the fuck out of here!
If we're going to have property tax it should be assessed on the price you paid for the property. Otherwise it's essentially a wealth tax penalizing an unrealized capital gain.
#nevent1q…d300
This looks like it might be good. I think I'm going to watch it tonight. Don't fucking spoil it for me if you've seen it.
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Nigger plz. Y'all wanna say nostr is dead I don't see you trying to keep this party alive.
WORD5 #715 4/6* (Hard Mode)
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https://otherstuff.ai/word5/
# Nostr is so fucking live! 🔥
#nevent1q…9p2n
When you run longer distances, there's a point where this euphoria kicks in. It can be kind of addicting.
I used to run ten milers pretty often in my 20s.
My great grandmother lived to 98 and she smoked every day of her life.
#nevent1q…zd2j
I think we have consensus. Fuck City living.
#nevent1q…vkkf
The one nice thing about our shitty hospital back home is that they would designate me a caregiver and charge my meals to our insurance, because fuck those insurance companies.
They don't do that here. I just paid $22 for my dinner.
May I have your attention please:
@nprofile…w9ld sucks tranny dick.
That is all.
Yeah that app is very snoopy!
Momma sed rock n roll is the devil's music!
Who TF said this motherfuckin shit is broken?? I'll fight that motherfucker!
@nprofile…w9ld sucks tranny dick.
I might murder you for my own amusement, but I won't steal your Bitcoin.
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None of what you just said even remotely applies to Monero, which is what we're talking about here.
I'm pretty sure it was the CIA that spun this narrative that transparency is more important than privacy.
You're not doing right. Go play blackjack and then when you're drunk enough ask a stripper to marry you.
Satoshi said he was moving on to other things. Many of the Monero devs are anonymous. I sometimes wonder if he's been quietly contributing under a different nym.
# Comparing mitragynine to opioids
Mitragynine has opioid activity—it is not pharmacologically separate from opioids. It is the main alkaloid in kratom and acts on the same μ-opioid receptor (“mu receptor”) targeted by morphine and other opioid painkillers. The useful comparison is therefore between mitragynine’s atypical opioid pharmacology and that of conventional opioid drugs, rather than “kratom compound versus opioid.”
The main functional differences concern how strongly it activates that receptor, what your body converts it into, and which other biological systems it affects.
1. It activates opioid receptors differently
Drugs such as morphine produce substantial μ-receptor activation, which contributes to both pain relief and potentially dangerous suppression of breathing. Mitragynine has comparatively low intrinsic efficacy at the human μ receptor: in laboratory studies, it behaves as a partial agonist, activating the receptor less strongly than a full agonist can in the same experimental system.
Think of receptor binding and receptor activation as two separate properties. A drug can attach to a receptor without turning its activity up very much. Consequently, “partial agonist” does not simply mean “a smaller dose of a strong opioid.” It describes a different ability to activate the receptor. The resulting effects still depend on the tissue, dose, and other compounds present.
This distinction is not unique to mitragynine. Buprenorphine is also a partial μ-opioid agonist, so not all conventional opioid medications belong on the “full agonist” side of the comparison. Sharing partial agonism does not make mitragynine and buprenorphine interchangeable.
2. Its metabolite is an important part of the story
Mitragynine can be converted into 7-hydroxymitragynine, commonly abbreviated 7-OH, through metabolism involving the enzyme CYP3A4. That metabolite has substantially greater opioid-receptor potency than mitragynine itself. Researchers demonstrated this conversion in human liver preparations and found that the metabolite accounted for much of mitragynine’s opioid-mediated pain relief in mice. The exact contribution to effects in humans is less firmly established.
This means that what mitragynine does in an isolated receptor experiment is not necessarily what happens after someone swallows it. The parent compound and the metabolites formed afterward can have different effects.
It also means that ordinary kratom leaf, purified mitragynine, and products enriched with 7-OH should not be treated as equivalent. Natural leaf contains relatively little 7-OH; concentrated products can expose someone directly to much larger amounts of this more potent compound.
3. Its effects are not exclusively opioid effects
Mitragynine’s pharmacology extends beyond μ-opioid receptors. For example, laboratory and animal studies have investigated interactions with alpha-2 adrenergic receptors, part of the system that responds to norepinephrine. However, receptor binding does not automatically establish a meaningful effect in humans, and the experimental findings are not simple enough to describe mitragynine as merely “an opioid plus a stimulant.”
There is another distinction here: kratom is a mixture, whereas mitragynine is one molecule. Kratom contains numerous other alkaloids, so an effect reported after taking kratom cannot automatically be attributed to mitragynine alone.
4. Breathing suppression may differ—but “it cannot suppress breathing” is wrong
There is experimental evidence that mitragynine’s respiratory effects differ considerably from those of morphine. In a 2025 rat study, intravenously administered mitragynine increased breathing frequency rather than suppressing it, whereas 7-OH and morphine both caused significant respiratory depression. Naloxone reversed the breathing suppression caused by 7-OH and morphine. High-dose mitragynine nevertheless caused seizure-like toxicity in some animals. These findings do not establish a safe dose or a guaranteed respiratory ceiling for oral use in humans.
You may encounter an explanation that mitragynine favors G-protein signaling over β-arrestin recruitment, two processes associated with opioid-receptor activation. Laboratory studies support this distinctive signaling profile. But the popular conclusion—“it avoids β-arrestin, therefore it cannot cause an opioid overdose”—goes beyond the evidence.
Broader opioid research suggests that low receptor-activating efficacy, not necessarily signaling bias alone, may explain some improved safety profiles. The relative contributions remain debated; neither characteristic is a guarantee against respiratory depression.
5. Dependence and other opioid-type effects remain possible
Kratom products can produce nausea, constipation, sedation, tolerance, physical dependence, and withdrawal. Their atypical pharmacology does not eliminate these possibilities. Human evidence also does not establish a reliable, universal conversion between a quantity of mitragynine and an equivalent dose of a prescription opioid. Kratom and its alkaloids are not FDA-approved treatments for pain or opioid withdrawal.
Bottom line: Mitragynine is best understood as an atypical opioid-active compound with relatively low μ-receptor efficacy, additional non-opioid actions, and a more potent opioid metabolite. Those differences can meaningfully change its effects compared with morphine—but they do not make it opioid-free, non-dependence-forming, or incapable of serious toxicity. Mitragynine and concentrated 7-OH are especially important not to conflate.
No, I'm not going to apply for a conceal carry permit. The Second Amendment is my license to be armed, and I need no other.
#nevent1q…nafx
People still getting paid to shill hardware wallets.
#nevent1q…j3kx
Stay strapped or get clapped.
They really hate freedom here in Washington. I'm from Montana so if course I have a loaded gun in the car with me whenever I travel, but if I were to get pulled over with it here it would cause an issue for me.
You should be able to walk into a shop and buy pharmaceutical grade heroin. Some people can handle it. Some can't. We should stop trying to protect the ones who can't and just let them self-select themselves for extinction.
You're not gonna pull out 10k cash and put it all on black?
Probably shouldn't use a surveillable currency then...
#nevent1q…yq7k
That's part of it. We protect the stupid and weak from harming themselves, and we also reward mediocrity more and more in our society.
That's what eugenics was trying to do but then everybody was like OMG that's so evil! 😭
Brains are crazy. My wife is awake now, but most of her brain has not activated yet according to the EEG. Mentally she's an infant. She can't speak or understand, and her muscle movements are involuntary. She's starting to recognize things though. Sometimes if I smile at her she'll smile back at me. I was showing her pictures and videos and it showed reactivity on the EEG that wasn't there a few days ago. Over the next several days they tell me more parts of her brain will come back online and she'll start getting her functions back.
Physiognomy is undefeated. I tried shaving my head for a while when I was a young man, but I learned pretty quickly that I scare people away like that. I have very pronounced skull ridges where my cranial bones meet, so when people see me with a shaved head they think I look like a psychotic, violent criminal. The thing is, I do actually have lots of violent ideations and impulses, I just mostly keep them under control unless a get a good deal of alcohol in me. It's one of those legitimate generic sciences that was unfairly rejected around a century ago that we should probably revisit.
Taking a shower in the hospital is always disappointing, because the water doesn't get very hot for safety reasons, whereas my preferred shower temperature is about one degree below suffering first degree burns all over my body.
https://i.nostr.build/6lA8kOh9hNRQBIm2.jpg
#nevent1q…tgtj
@nprofile…w9ld sucks tranny dick.
At least on-chain zaps encourage people to actually send value. Honestly, don't bother zapping me if you're not going to buy me a coffee or beer. If you can only afford 21 sats then you probably need it more than me, thanks.
#nevent1q…8uct
John Carvalho sucks tranny dick.
#nevent1q…92m7
@nprofile…w9ld sucks tranny dick.
I would have tolerated a certain amount of graft from this administration had they at least been more effective in implementing the points laid out in Agenda 2025.
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