Last Notes
My wife, the podiatrist, says I've got a couple of feet 😂
Refer to this meme
Take the L @npub1m2u…y2gl
https://node.blossom.band/f7455b7b1558c8fe91226534ab95f3fa8736a48db8a8b64543c9e9a3cdae3689.jpg
I can hear the overmind regardless
Have to do something since my hair powers are gone 🥺
Someone for everyone is what my mom used to say 🤷♀️
Heyyyy Mehple. That sounds amazing. Thank you and same to you brother
Gents in a hospital near you™
Quite possibly...maybe she still has it and I can tape it back on 🤔
Satoshi said he was moving on to other things. Many of the Monero devs are anonymous. I sometimes wonder if he's been quietly contributing under a different nym.
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Fun stuff, I still have an appendix but I'm down a gallbladder. That deflating after the surgery was terrible 🥺🫂.
https://i.nostr.build/OktHnkBlvxInx64c.gif
If you crop it just right, it's kinda a sexy pic
https://i.nostr.build/CG9UL6N6C8aNCEl61Fu5qM.jpg
All these Brits and their pies, amirite 😂🤷♀️
Hey try having your appendix out and then see how you function 😂
https://i.nostr.build/VCfBZMqFSnThIoAlI7i4JW.jpg
In search of the elusive PoW 32: well over a day in, we're at 726000k mined. lulz.
🤷♀️😂 I'm not functioning at 100% Mike. I apologize
That post did numbers on Xitter, LMAO.
Damn, that joke missed by a country mile 🥹
LGBT is Satanic Law.
https://blossom.primal.net/1cc740fc18c6471b0a2930f3eea90abacc1f8eb4ba430f66d3efbcf89cf43924.png
👀 we talking like the beef pot pie I posted a week or so ago? Or am I forgetting a convo...it's been a busy week of peopling for me.
I tried making that humble pie the other day.
NGL, it was the best thing I ever made 😂
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There's a bag somewhere for you...it's full of things to eat...👀😂
But it has to be pressed, not talked about 🤷♂️
WORD5 #714 4/6* (Hard Mode)
⬛⬛🟧⬛⬛
🟧🟧🟪⬛⬛
⬛⬛🟪🟧🟧
🟪🟪🟪🟪🟪
https://otherstuff.ai/word5/
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NIP-62 request to vanish in Armada's settings.
https://blossom.ditto.pub/3c70d9bd8c0cc610ef4d6e5ab0110c5e057bfaae7dfecee726224842b01c9cb1.webp
Maniacally installing Omarchy on every piece of otherwise dead-tech I have sitting around the place
Yes. I’m using Google Drive to store encrypted backups. Google can see the encrypted data, but not the contents of my files.
The original post referenced in this quote post has the full details.
You're not doing right. Go play blackjack and then when you're drunk enough ask a stripper to marry you.
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I stopped by the organic wine shop today that I sell my #hodlbutter at and picked up a bottle in sats. Feels good.
Had the owner try my new cookies and he absolutely loved them. He’s a chef from NYC that owns a couple of restaurants up there so it meant a lot to get his praise on them.
Same for one of the bakers at the farmers market that I’m friends with; he’s quite well known in the area for his pastries and other goods. He also had a lot of kind words on my product. He loves the pecan butter.
Making friends with people that have good taste is quite fun.
Farmers market tomorrow. Brining some cookies with me. Let’s see how they do 🤞🏼
https://image.nostr.build/35a0b6616f5b3507768f8da2b28d2d6b0f40100bca6b8d1711c281382a795d35.jpg
https://image.nostr.build/55bf1dcc132ee1fa0e18aa28218298abec33c22b087e6765f2059677e8b47a56.jpg
He didn’t delete anything. He just rage quit and threw his toys out of the crib because he couldn’t accept that nobody gives a shit about him or his products.
Keep going. It's like entering developer mode on your android phone. You know you're almost there when your eye goes red.
Who would write such a phrase and then put quiet unrelated pictures with it? There are very clear uncontroversial representatives for information control. But those shown are nowhere close to those I am talking about.
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Perhaps we should rename it to stalking 😂
I think I just deleted the internet.
# Comparing mitragynine to opioids
Mitragynine has opioid activity—it is not pharmacologically separate from opioids. It is the main alkaloid in kratom and acts on the same μ-opioid receptor (“mu receptor”) targeted by morphine and other opioid painkillers. The useful comparison is therefore between mitragynine’s atypical opioid pharmacology and that of conventional opioid drugs, rather than “kratom compound versus opioid.”
The main functional differences concern how strongly it activates that receptor, what your body converts it into, and which other biological systems it affects.
1. It activates opioid receptors differently
Drugs such as morphine produce substantial μ-receptor activation, which contributes to both pain relief and potentially dangerous suppression of breathing. Mitragynine has comparatively low intrinsic efficacy at the human μ receptor: in laboratory studies, it behaves as a partial agonist, activating the receptor less strongly than a full agonist can in the same experimental system.
Think of receptor binding and receptor activation as two separate properties. A drug can attach to a receptor without turning its activity up very much. Consequently, “partial agonist” does not simply mean “a smaller dose of a strong opioid.” It describes a different ability to activate the receptor. The resulting effects still depend on the tissue, dose, and other compounds present.
This distinction is not unique to mitragynine. Buprenorphine is also a partial μ-opioid agonist, so not all conventional opioid medications belong on the “full agonist” side of the comparison. Sharing partial agonism does not make mitragynine and buprenorphine interchangeable.
2. Its metabolite is an important part of the story
Mitragynine can be converted into 7-hydroxymitragynine, commonly abbreviated 7-OH, through metabolism involving the enzyme CYP3A4. That metabolite has substantially greater opioid-receptor potency than mitragynine itself. Researchers demonstrated this conversion in human liver preparations and found that the metabolite accounted for much of mitragynine’s opioid-mediated pain relief in mice. The exact contribution to effects in humans is less firmly established.
This means that what mitragynine does in an isolated receptor experiment is not necessarily what happens after someone swallows it. The parent compound and the metabolites formed afterward can have different effects.
It also means that ordinary kratom leaf, purified mitragynine, and products enriched with 7-OH should not be treated as equivalent. Natural leaf contains relatively little 7-OH; concentrated products can expose someone directly to much larger amounts of this more potent compound.
3. Its effects are not exclusively opioid effects
Mitragynine’s pharmacology extends beyond μ-opioid receptors. For example, laboratory and animal studies have investigated interactions with alpha-2 adrenergic receptors, part of the system that responds to norepinephrine. However, receptor binding does not automatically establish a meaningful effect in humans, and the experimental findings are not simple enough to describe mitragynine as merely “an opioid plus a stimulant.”
There is another distinction here: kratom is a mixture, whereas mitragynine is one molecule. Kratom contains numerous other alkaloids, so an effect reported after taking kratom cannot automatically be attributed to mitragynine alone.
4. Breathing suppression may differ—but “it cannot suppress breathing” is wrong
There is experimental evidence that mitragynine’s respiratory effects differ considerably from those of morphine. In a 2025 rat study, intravenously administered mitragynine increased breathing frequency rather than suppressing it, whereas 7-OH and morphine both caused significant respiratory depression. Naloxone reversed the breathing suppression caused by 7-OH and morphine. High-dose mitragynine nevertheless caused seizure-like toxicity in some animals. These findings do not establish a safe dose or a guaranteed respiratory ceiling for oral use in humans.
You may encounter an explanation that mitragynine favors G-protein signaling over β-arrestin recruitment, two processes associated with opioid-receptor activation. Laboratory studies support this distinctive signaling profile. But the popular conclusion—“it avoids β-arrestin, therefore it cannot cause an opioid overdose”—goes beyond the evidence.
Broader opioid research suggests that low receptor-activating efficacy, not necessarily signaling bias alone, may explain some improved safety profiles. The relative contributions remain debated; neither characteristic is a guarantee against respiratory depression.
5. Dependence and other opioid-type effects remain possible
Kratom products can produce nausea, constipation, sedation, tolerance, physical dependence, and withdrawal. Their atypical pharmacology does not eliminate these possibilities. Human evidence also does not establish a reliable, universal conversion between a quantity of mitragynine and an equivalent dose of a prescription opioid. Kratom and its alkaloids are not FDA-approved treatments for pain or opioid withdrawal.
Bottom line: Mitragynine is best understood as an atypical opioid-active compound with relatively low μ-receptor efficacy, additional non-opioid actions, and a more potent opioid metabolite. Those differences can meaningfully change its effects compared with morphine—but they do not make it opioid-free, non-dependence-forming, or incapable of serious toxicity. Mitragynine and concentrated 7-OH are especially important not to conflate.